Subtype of circulating tumor cells with relapse in resected Stage I lung adenocarcinoma
- #AA -O-5
- AATS Foundation Award
- Oral
Subtype of circulating tumor cells with relapse in resected Stage I lung adenocarcinoma
Yanbin Sun
Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, China
Date, time and location: 2018.05.26 17:00, Congress Hall, 2F–C
Abstract
Objectives
More than 20% of lung adenocarcinoma
patients develop recurrence, even in the stage I after surgical resection. In
the process of recurrence, circulating tumor cells (CTCs) may play a important
role. The present study evaluated the influence of CTCs on recurrence in
resected stage I lung adenocarcinoma patients. Further, we evaluated the subtype
of CTCs on recurrence in the patients.
Methods
Blood samples for CTCs analysis were
obtained from 106 patients in pathological stage I adenocarcinoma both before
and one month after surgical resection in first hospital of China medical
university from 2011-1013. CTCs were isolated with immunomagnetic techniques.
Recurrence free survival (RFS) analysis was perfomed.
Results
CTCs were detected in 29.2%(31/106) of patients
before surgery and in 14.2%(15/106) one month after surgery. The presence of CTCs(both
before surgery and after surgery) was significantly correlated with CEA,
pathological subtype, and surgical approach(p<0.05).
25 patients(23.6%) experienced recurrence.
The presence of CTCs after surgery was significantly associated with recurrence(p<0.001)
and with a shorter RFS, with 3-year RFS rate of 40% compared to 82.4% for CTCs
negative group. In multivariate analysis, the presence of CTCs after surgery
was an independent factor for the RFS.
Conclusions
The presence of CTCs after radical resection
might be an useful marker to predict the recurrence in the early stage lung
adenocarcinoma. SUVmax value on preoperative PET scan and CEA were
associated with the presence of CTCs after the operation.